Enhancement of adenovirus transformation by treatment of hamster embryo cells with diverse chemical carcinogens.

./V-acetoxy-acetylaminofluorene; but no increase was demon strated when cells were treated with ./V-nitrosodiethylamine, yV-nitrosodimethylamine, or 2-acetylaminofluorene. The frequency of viral transformation increased linearly with chemical concentration until a maximum level was reached; however, higher concentrations decreased the trans formation frequency relative to that observed with lower doses. It is suspected that the chemical carcinogens enhance viral transformation by interacting directly with the host cells, rendering them more susceptible to transformation by virus.